As one of the five internal organs of the human body, the liver is closely related to the body's normal metabolism, detoxification, blood coagulation, and other processes. The liver participates in the body's immunity, it is an indispensable important organ for maintaining the bod…
2020-06-09
The combination of liver cell line and CRISPR/Cas9 helps to study medical problems such as hepatitis, genetic diseases and cancer
2020-05-12
Many experiments of gene knockout/knockdown/overexpression circRNA cell line has been preformed to study complex functions of circRNA, and there are serveral functions has been found.
2020-03-09
The success rate of gene kockout human iPSC cell is lower because, unlike tumor cell lines, iPSC does not have the characteristics of chromosomal abnormality and strong ability of DNA repair. CRISPR/Cas9 has the advantages of high efficiency, easy to construct and low toxicity in …
2020-03-02
The success rate of knockout THP-1 cell lines is very low by conventional gene-editing methods, because THP-1 is a near-tetraploid suspension cell. CRISPR/Cas9 is widely used to construct gene-editing THP-1 model because of its simple, high efficiency and low toxicity.
2020-02-24
The success of positive single-cell cloning is technically challenging, because of the long growing time and the low efficiency. Ubigene has have built up a set of unique experimental methods and processes, which can achieve the efficiency of single-cell clone formation 3-5 times …
2020-01-15
Ubigene developed CRISPR-U™(based on CRISPR/Cas9 technology) which is more efficient than general CRISPR/Cas9 in double-strand breaking, and CRISPR-U™ can greatly improve the efficiency of homologous recombination.
2020-01-06
With the progress of studying microRNA, it is revealed that ncRNA plays an important role in post-transcriptional regulation, cell growth, differentiation and proliferation. MicroRNA, circRNA and lncRNA are the most commonly studied ncRNA.Locus knockout and promoter knockout are t…
2019-10-19
In recent years, the emerging CRISPR gene editing technology is widely used in almost every biological field. Because of its high specificity, low off-target effect and wide application prospects, CRISPR is replacing RNAi as the best choice for most research.
2019-09-12
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