Single-cell CRISPR screens enable the exploration of mammalian gene function and genetic regulatory networks. Recently, multiple techniques have emerged that pair CRISPR screens with high-throughput single-cell RNA sequencing (scRNA-seq), resulting in high resolution, information-…
2020-07-06
Researchers have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused the diabetes…
2020-07-03
White House officials have released guidelines to help states decide how — and when — to loosen social distancing measures in a way that prevents the coronavirus from surging back. But health experts say beginning to open parts of society during the pandemic hinges on the avai…
2020-07-02
In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins …
2020-07-01
Speed and accuracy are qualities that all scientists look for in their experiments, and with genome engineering studies becoming ever more ubiquitous, these attributes are more critical than ever. Large scale gene editing assays need to be checked quickly for clones that have the …
2020-06-30
Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA. The ability of CRISPR gene-editing technology to safely modify human embryos has been cast into doubt after several recent papers described massive di…
2020-06-29
Victoria Gray, who underwent a landmark treatment for sickle cell disease last year, has been at home in Forest, Miss., with her three kids, Jadasia Wash (left), Jamarius Wash (second from left) and Jaden Wash. Victoria Gray , NPR Nearly a year on, Victoria Gray, who was the first…
2020-06-28
It might seem that dulling a cutting tool is the last thing an engineer would want to do, but Stanley Qi is no ordinary engineer. By blunting the gene-editing scissors known as CRISPR/Cas9, he made them even more useful — the molecular equivalent of a Swiss Army knife. CRISPR/Ca…
2020-06-24
A research team from Germany and Italy presents a MorphoSeq computational approach for coming up with a "canonical digital embryo" based on single-cell RNA sequencing (scRNA-seq) and light-sheet imaging data on individual cells. The researchers applied this approach to Phallusia m…
2020-06-23
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